How does tzd work

Our mission is to help individuals better understand their diabetes and to make our readers happier and healthier. Thiazolidinediones TZDs , also known as glitazones, are a type of medication that people with type 2 diabetes can use to lower blood sugar levels by reducing insulin resistance. TZDs work by binding to a protein in cells called the peroxisome proliferator-activated receptor gamma, or PPAR gamma to activate genes and create new proteins that reduce insulin resistance.

TZDs are used by people with type 2 diabetes who need additional methods of lowering blood glucose beyond what metformin or other treatments can provide. Discuss this risk with your healthcare professional and whether you might benefit from another glucose-lowering medication such as GLP-1 agonists or SGLT-2 inhibitors. Forman B. M Forman B. Cell 83 : — Fujita T Fujita T.

Diabetes 32 : — Guan H. Google Scholar. Lehmann J. M Lehmann J. Picard F Picard F. Rangwala S. M Rangwala S. Trends Pharmacol. Tzameli I Tzameli I. Wagner B. L Wagner B. Cell Biol. It is possible that the effect of TZDs on insulin resistance in muscle and liver is promoted via endocrine signalling from adipocytes. Potential signalling factors include free fatty acids FFA well-known mediators of insulin resistance linked to obesity or adipocyte-derived tumour necrosis factor-alpha TNF-alpha , which is overexpressed in obesity and insulin resistance.

Although there are still many unknowns about the mechanism of action of TZDs in type 2 diabetes, it is clear that these agents have the potential to benefit the full 'insulin resistance syndrome' associated with the disease. Therefore, TZDs may also have potential benefits on the secondary complications of type 2 diabetes, such as cardiovascular disease.